Compounds / Selank

Selank

Also known as: TP-7, tuftsin analogue

Early clinical Not FDA-approved · registered in Russia Category: Nootropic

The compounds described in this library are research-use-labeled chemicals and are not FDA-approved for human use. This content is factual scientific reference drawn from published literature. It is not medical, dosing, or purchasing advice. VialReport does not sell, supply, or distribute any compound.

Short summary

A synthetic heptapeptide derived from the immune peptide tuftsin, developed in Russia and registered there for anxiety-related indications. Not FDA-approved, with the same evidence-base caveat as Semax.

Dive deeper

Origin and Development

Developed at the same Russian research institute as Semax, based on the endogenous immune peptide tuftsin with a stabilizing modification. Registered in Russia as an anxiolytic.

Mechanism as Understood in the Literature

Described in the literature as influencing GABAergic signaling and as modulating expression of brain-derived neurotrophic factor, along with effects on enkephalin degradation. As with Semax, mechanistic detail is less developed than the clinical claims.

Research Status

Clinical work exists, again predominantly Russian, examining anxiety and related conditions. Independent international replication is limited.

Regulatory status

Not FDA-approved for any indication. Registered as a medicine in Russia.

Commonly Confused With

Routinely sold and discussed together with Semax to the point that the two are treated as a pair. They come from the same research program but are different molecules with different parent sequences: Selank derives from tuftsin, Semax from ACTH. Their described effects differ correspondingly.

How This Compound Is Marketed

Vendor marketing for this compound typically references anxiety, stress, and mood. VialReport does not evaluate or endorse these claims. See Research Status above for what the published literature actually establishes.

Analytical Profile

Seven amino acids, sequence TKPRPGP, molecular weight approximately 751 Da. Close in size to Semax, so the two should be distinguished by mass against the correct reference rather than by retention time alone, particularly given how often they are sold together.

Stability and Handling

Supplied lyophilized. Stable lyophilized at reduced temperature.

Key Literature

  1. 01 Zozulya AA, et al. The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Bull Exp Biol Med. 2001;131(4):315-317.
  2. 02 Kolomin T, et al. Transcriptomic response of rat hippocampus and spleen cells to single and chronic administration of the peptide Selank. Dokl Biol Sci. 2010;430:5-8.

VialReport publishes factual reference information and independent test data. Nothing here is medical, dosing, or purchasing advice.

Published reports

Reports for Selank

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