Compounds / Kisspeptin-10

Kisspeptin-10

Also known as: KP-10, metastin 45-54

Early clinical Not FDA-approved Category: Other

The compounds described in this library are research-use-labeled chemicals and are not FDA-approved for human use. This content is factual scientific reference drawn from published literature. It is not medical, dosing, or purchasing advice. VialReport does not sell, supply, or distribute any compound.

Short summary

A ten-amino-acid fragment of kisspeptin, a peptide central to the regulation of reproductive hormone signaling. It has a legitimate and active academic research literature, including human studies, though it is not approved for any use.

Dive deeper

Origin and Development

Kisspeptin was originally identified as a metastasis suppressor (metastin) before its central role in reproductive endocrinology was recognized. Kisspeptin-10 is the shortest fragment retaining full receptor activity.

Mechanism as Understood in the Literature

Agonist at the kisspeptin receptor (KISS1R, formerly GPR54) on hypothalamic neurons, where it acts as a principal upstream regulator of gonadotropin-releasing hormone secretion, and therefore of LH and FSH. Its role in initiating puberty is well established.

Research Status

Genuinely active academic research, including human studies conducted by university groups examining reproductive endocrinology, hypothalamic function, and fertility applications. This is a compound where the underlying science is well grounded, in contrast to several others in this library. [VERIFY BEFORE PUBLICATION: FDA 503A/503B bulk drug substances status for kisspeptin-10.]

Regulatory status

Not FDA-approved for any indication.

Commonly Confused With

Several kisspeptin fragments exist, including kisspeptin-54, kisspeptin-13, and kisspeptin-14, all derived from the same precursor and differing in length and half-life. A vial labeled simply kisspeptin may be any of them.

How This Compound Is Marketed

Vendor marketing for this compound typically references hormone support, libido, and fertility. VialReport does not evaluate or endorse these claims. See Research Status above for what the published literature actually establishes.

Analytical Profile

Ten amino acids, molecular weight approximately 1302 Da. The existence of multiple named fragments of differing length makes verification against the correct reference standard particularly important for this compound.

Stability and Handling

Supplied lyophilized. Kisspeptin-10 has a notably short circulating half-life, which is relevant context for interpreting any research using it.

Key Literature

  1. 01 [REPLACE: needs a kisspeptin-10-specific human study. The commonly cited Dhillo 2005 paper administered kisspeptin-54, not KP-10, and cannot serve as direct evidence for this entry.]
  2. 02 Jayasena CN, et al. Kisspeptin: a novel therapeutic target in reproduction. (review) Trends Pharmacol Sci. 2014.

VialReport publishes factual reference information and independent test data. Nothing here is medical, dosing, or purchasing advice.

Published reports

Reports for Kisspeptin-10

No reports for this compound yet.

Want a vendor’s version of this compound tested? Request it and we’ll notify you when a report publishes.

Request a test

Stay current

Get notified when new reports publish.

No membership required. We email findings when they're published. Not updates, not promotions, just reports.

Powered by MailerLite. No spam. Unsubscribe anytime.