Compounds / Sermorelin

Sermorelin

Also known as: Sermorelin acetate, GRF 1-29, Geref (discontinued brand)

Established human clinical Formerly FDA-approved · brand discontinued Category: Growth Hormone Secretagogues

The compounds described in this library are research-use-labeled chemicals and are not FDA-approved for human use. This content is factual scientific reference drawn from published literature. It is not medical, dosing, or purchasing advice. VialReport does not sell, supply, or distribute any compound.

Short summary

A synthetic peptide comprising the first 29 amino acids of growth hormone-releasing hormone. It was previously FDA-approved as a prescription medicine and has an unusually solid clinical history for a compound in this category, though the branded product was discontinued.

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Origin and Development

Sermorelin is the unmodified biologically active fragment of human GHRH, residues 1 to 29. It was developed as a pharmaceutical and marketed in the United States under the brand name Geref, used in the diagnosis and treatment of growth hormone deficiency, particularly in pediatric populations.

Mechanism as Understood in the Literature

GHRH receptor agonist. It prompts the pituitary to release endogenous growth hormone, preserving the body's own feedback regulation rather than supplying exogenous growth hormone.

Research Status

Substantially better characterized than most compounds in this library. It went through conventional pharmaceutical development, received marketing approval, and was used clinically in diagnostic and therapeutic contexts before the branded product ceased to be marketed.

Regulatory status

Sermorelin acetate was previously FDA-approved under the Geref brand for pediatric growth hormone deficiency. That product is no longer marketed. Present compounded preparations are not FDA-approved products and may differ in formulation, manufacturing controls, and supporting data. The historical approval does not extend to material sold today. Prohibited in competitive sport under World Anti-Doping Agency rules, as GHRH analogues are banned at all times. Note: an unsupported claim about the reason for the brand's market withdrawal has been removed from this entry; compounded material is distinguished from the historical approval above.

Commonly Confused With

Sermorelin is the parent sequence that CJC-1295 and Mod GRF 1-29 were built from. CJC-1295 adds four amino acid substitutions for stability; the DAC version adds an albumin-binding complex on top of that. Sermorelin itself has none of those modifications and therefore a much shorter duration of action.

How This Compound Is Marketed

Vendors in this market commonly market this compound for growth hormone support, anti-ageing, recovery, and sleep, none of which follow from the historical pediatric growth hormone deficiency approval. These are vendors’ marketing claims, not VialReport’s. VialReport does not verify, evaluate, or endorse them, and nothing on this page is medical, dosing, or purchasing advice or a recommendation to use any compound. See “Research status” above for what the published literature actually establishes.

None of these follow from the historical pediatric growth hormone deficiency approval described above.

Analytical Profile

29 amino acids, molecular weight approximately 3358 Da. As the unmodified parent sequence, it is readily distinguished by mass from CJC-1295 and its DAC variant.

Stability and Handling

Supplied lyophilized. Reconstituted material requires refrigeration and has a limited usable window.

Key Literature

  1. 01 Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999;12(2):139-157.
  2. 02 Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006;1(4):307-308.

VialReport publishes factual reference information and independent test data. Nothing here is medical, dosing, or purchasing advice.

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